The time of day that a patient with severe asthma is seen in clinic could impact the ability to accurately diagnose and effectively treat the condition, new research suggests.
The most comprehensive circadian study of biomarkers in asthma to date has shown that time of day is crucial when measuring biomarkers in asthma, particularly if they are being used to inform management decisions.
Results showed that sputum eosinophil levels taken from an asthma patient in the morning were significantly higher than those taken from the same patient in the afternoon.
While the findings need to be confirmed in a prospective study, the implications are clinically important, say the researchers led by Dr Hannah Durrington, Senior Clinical Lecturer at the University of Manchester and Honorary Consultant in Respiratory Medicine, Wythenshawe Hospital, Manchester University NHS Foundation Trust.
“In severe asthma, having raised sputum eosinophils is an indicator for treatment escalation; we propose that based on our results different clinical decisions could be made based on whether the patient is allocated a morning or afternoon appointment,” they said.
The study, published in the American Journal of Respiratory and Critical Care Medicine, looked at circadian variation of blood and sputum eosinophils in 10 patients with mild/moderate atopic asthma compared to 10 controls, and then retrospectively compared sputum eosinophil counts from severe asthma patients attending either morning (131 patients) or afternoon clinic (193 patients).
Dr Durrington told the limbic: “We already know that airway obstruction in asthma varies by time of day and is worse around 4 am. This research demonstrates that sputum eosinophils vary by time of day in mild/moderate asthma and are highest at 4 am and lowest in the afternoon at 4 pm.
“However, sputum eosinophil counts are still significantly raised later in the morning (within the clinical working day) in severe asthma patients, compared to the in the afternoon – this is a new finding.”
Severe asthma patients attending morning clinic were almost twice as likely to have sputum eosinophilia (³3%) compared to patients attending afternoon clinic (37.4% vs 21.6%). There was no significant variation in sputum eosinophils in healthy volunteers.