Cancer specialists from several countries have used the American Association for Cancer Research’s virtual meeting to report their early experiences of the impact of COVID-19 disease in cancer patients, including how lung involvement may be a risk for higher mortality.
Dr Carlos Gomez-Martin from Madrid, Spain, told the meeting that of the first 63 patients with cancer and COVID-19 admitted at his institution, more than half developed respiratory failure, nearly 40% developed ARDS and 25% died. He noted that patients with cancer with lung involvement, an ECOG status of 2 or higher, severe neutropenia, or those with bilateral lung infiltrates during their baseline CT scan had significantly increased mortality.
To further investigate the impact of COVID-19 disease in lung cancer patients, Italian oncologists have set up a global registry, called TERAVOLT (Thoracic cancERs international coVid 19 cOLlaboraTion), which has already accumulated reports from 260 patients with thoracic cancers.
“The goals of this consortium are to provide data for guidance to oncology professionals on managing patients with thoracic malignancies while understanding the risk factors for morbidity and mortality from this novel virus,” said Dr Marina Chiara Garassino from Istituto Nazionale dei Tumori in Milan.
Dr Garassino said their analysis of outcomes for the first 200 patients – mostly with NSCLC- enrolled in TERAVOLT registry suggested that COVID-19 was associated with more severe complications in patients with thoracic cancers.
The most reported complication in this patient population was pneumonia/pneumonitis, affecting almost 80% of evaluable patients. Further, almost 27% of patients had ARDS. Over 75% of patients were hospitalised, and almost 35% of patients died, either at the hospital, in the ICU, or at home.