Faecal microbial transplantation has been suggested as a treatment option for fulminant C. difficile colitis by clinicians in Tasmania who used it successfully in a patient as an alternative to colectomy.
While FMT has high efficacy and is recommended in guidelines for nonfulminant C. difficile infection (CDI), it may be underutilised in fulminant CDI because of uncertainties about its efficacy and risks of delaying surgery, according to a team at the Royal Hobart Hospital.
In a case report published in Internal Medicine Journal (link here) they argue that FMT may have a a role as an alternative treatment to surgery, “where a delay to potential colectomy is clinically acceptable.”
In their report they describe the case of a female patient in her 50s who was hospitalised with severe CDI after taking courses of antibiotics for sinusitis.
On initial presentation CT of the abdomen and pelvis showed colitis of the caecum, most of the ascending colon (to just proximal to the hepatic flexure), and descending colon, with prominent pericolic stranding, and a maximum transverse colon diameter of 5 cm
Despite treatment with aggressive fluid resuscitation, oral vancomycin and i.v. metronidazole she showed progressive colonic dilatation and development of ileus.
Laboratory markers of persisting raised white cell count, raised creatinine, lactate and hypoalbuminaemia, as well as altered mental status, corresponded with severe disease.
By day 8 she showed continued progression of colonic inflammation, distention and peritonism, with an abdominal X-ray showing a maximum transverse colon diameter of 13 cm.
Colectomy was considered at a multidisciplinary team meeting based on concern for toxic megacolon. However a consensus decision was made to trial FMT for 48 hours, based on senior gastroenterological experience with FMT, and CT findings, which showed ileus but ruled out colonic perforation and ischaemia.
Other factors in the decision to trial FMT were the treating teams’ desire to avoid the potential morbidity from a laparotomy and colectomy, and the patient’s desire to avoid a permanent colostomy.
Frozen FMT sample was flown in from Adelaide and administered via colonoscopy.