Effective treatment of many paediatric infections is threatened by “alarmingly high” rates of antibiotic resistance to commonly prescribed empirical therapies in the Asia–Pacific region, Australian research shows.
A study led by Dr Phoebe Williams from Sydney University’s School of Public Health found many antibiotics recommended by the World Health Organization (WHO) had less than 50% effectiveness in treating childhood infections such as pneumonia, sepsis and meningitis.
The findings, published in Lancet South East Asia (link here), show the most recent 2013 global guidelines on antibiotic use are outdated and need updates, according to Dr Williams, an infectious disease specialist at the Sydney Infectious Diseases Institute.
The researchers analysed data obtained from a systematic review of antibiotic susceptibility data for bacterial pathogens in the WHO SE Asia and West Pacific regions to provide local coverage estimates for aminopenicillins, gentamicin, third-generation cephalosporins and carbapenems.
Based on 6648 bacterial isolates from 11 countries, coverage provided by aminopenicillins in neonatal sepsis/meningitis was 26%, whilst gentamicin coverage was 45% . Third-generation cephalosporin coverage was only 29% in neonatal sepsis/meningitis, 51% in paediatric sepsis and 65% in paediatric meningitis.
Carbapenems were estimated to provide the highest coverage: 81% in neonatal sepsis/meningitis, 83% in paediatric sepsis and 79% in paediatric meningitis.
“In light of the growing burden of [antimicrobial resistance] in these settings, an urgent focus on improving our understanding of the available efficacious therapies that may reduce the morbidity and mortality of serious infections in children is required,” the study author said.
These data call into urgent question the adequacy of coverage currently provided by WHO-recommended first- and second-line antibiotic regimens, they added.
“Evaluation of potential alternative antibiotic regimens, targeted to local pathogen and [antimicrobial resistance] patterns, will be essential to reduce unnecessary morbidity and mortality for children in this region; whilst ensuring antimicrobial stewardship is optimised in the context of rapidly growing [antimicrobial resistance] worldwide, and ensuring antibiotic development programs promptly promote access to new agents to treat multi-drug resistant infections in children globally,” they wrote.