Consensus recommendations have beeb developed to guide clinicians in identifying a dominant pain phenotype in patients with low back pain.
The new recommendations “will add to the existing literature as a necessary early step in the process to determine if personalised pain medicine based on pain phenotypes is feasible for low back pain management,” the international group of authors said in a paper published in The Lancet Rheumatology (link here).
The group, comprised of experts from 13 countries, including Australia, has developed a seven-step “decision-making tree” to help identify the predominant pain mechanism – nociceptive, neuropathic or nociplastic – in patients with low back pain.
This calls on clinicians to consider the duration and distribution of low back pain, whether the pain is mainly caused by nociceptive or neuropathic mechanisms, pain hypersensitivity, and any comorbidities.
“The seven steps in the figure do not align with routine clinical care, but clinicians are advised to collect all information as they normally would and check the seven steps after,” the authors advised.
The expert group also developed a set of potential recommendations for low back pain management depending on pain phenotype.
For example, where pain is predominantly nociceptive, “treatment could plausibly be expected to be effective if it targets what is driving the nociceptive input.
“This implies that the first line treatment should target that nociceptive driver and this could include conservative interventions such as activity modifications (e.g., pacing periods of standing and walking), limited oral medications or topical treatment, physical therapy, lifestyle modifications, and selected, evidence-based intervention techniques,” they said.
Surgery can be considered in patients whose pain is not improved through “conservative management”, while pharmacological treatment should comprise short-term non-opioid analgesics such as NSAIDs and COX-2 inhibitors, depending on whether the nociceptive input is inflammatory or not, according to the paper.
“Opioids can be considered for predominant nociceptive low back pain only if established non-pharmacological treatments and established non-opioid analgesics are not effective, not tolerated, contraindicated, or not available,” the authors stressed.