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Professor Nicola Dalbeth
Hyperuricemia is not the sole driver of CVD risk and the persistent premature mortality observed in patients with gout, despite the narrative forged in observational studies over many years.
Speaking at ACR Convergence 2023 in San Diego, Professor Nicola Dalbeth said recent randomised studies have not supported elevated serum urate as causal for cardiovascular disease.
As an example, the 2022 ALL-HEART study [link here] in a large population with ischaemic heart disease but no gout found allopurinol up to 600 mg/day was effective urate lowering therapy but had no impact on the composite cardiovascular endpoint of non-fatal myocardial infarction, non-fatal stroke, or cardiovascular death compared to usual care.
“What we don’t know at this stage is whether there is the same lack of effect in people with gout. But … are we actually looking in the wrong place?”
Professor Dalbeth, from the University of Auckland and Auckland District Health Board, said a 2022 nested case-control study [link here] found a higher odds of either acute myocardial infarction or stroke soon after a gout flare.
“So maybe it’s not the urate; maybe it’s actually the acute inflammation that’s contributing.”
She said a number of studies had demonstrated cardiovascular benefits from low dose colchicine in post-MI and stable CVD populations. The question was whether there were similar benefits in gout patients.
“Certainly we really need more data … looking at whether there is in fact a cardiovascular benefit of low dose colchicine, specifically in the gout setting.”
Similarly, there was evidence for the cardiovascular benefits of canakinumab in the general population but not yet for CV benefits in gout patients.