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Dr Yai-Ling Zhang
Telomere length does not appear to impact outcomes in patients undergoing lung transplantation for fibrosing lung disease, the TSANZSRS 2024 meeting has heard.
Dr Lai-Yung Zhang presented a retrospective study of all 52 lung transplant recipients at the Queensland Lung Transplant Service who had their peripheral blood telomere length measured via Flow-FISH and had undergone transplantation for a fibrosing lung disease.
The study found 31 patients (59.6%) had a short telomere length defined as ≤10th centile and generally associated with younger onset, more severe lung disease, faster progression and extra pulmonary features.
Short-telomere recipients were demographically similar to normal-telomere recipients, with no statistically significant difference in age at time of transplant, gender, or underlying pre-transplant ILD diagnosis.
As well, short telomere length compared to normal telomere length did not appear to impact post-transplant bone marrow suppression and overall CLAD-free survival.
Short telomere length was not found to be associated with shorter time to any cytopenia, shorter time to clinically significant neutropenia, or cytomegalovirus viremia.
Dr Zhang, from the Prince Charles Hospital, told the limbic that while telomere length was not statistically associated with duration of cytopenia or duration of significant neutropenia post-transplant, there was a trend towards significance.
“So the number of days it takes for the patients to become cytopenic were quite similar across both groups, but the duration of cytopenia was very close to being significantly higher in the short telomere patients.”
“That being said, I think in this cohort of patients, the cytopenia that we most worry about is neutropenia … and interestingly, when you actually drill down into neutropenia alone, the time to first neutropenia was non significant, but there was a trend towards it being earlier in the normal telomere length patients rather than short telomere which is really interesting and not expected.”
“And the duration of clinically significant neutropenia requiring G-CSF administration, etc. was actually very clearly similar across both groups.”
No significant difference in time to chronic lung allograft dysfunction (CLAD) or death was found in short-telomere recipients compared to recipients with normal telomere length.
Reassuring results
Dr Zhang said the results were both surprising and somewhat reassuring.