Adult cystic fibrosis patients who need antibiotics for a pulmonary exacerbation may be at risk of overtreatment and undertreatment if the duration of treatment is stipulated in guidelines, an expert warns.
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Dr Michael Stephen
Writing in a comment piece published in the Lancet Respiratory Medicine, Associate Professor Michael Stephen from the Department of Pulmonary and Critical Care at Drexel University in Philadelphia, said the duration of antibiotic treatment for pulmonary exacerbations in people with CF was a subject of debate because guidelines had found insufficient evidence to recommend an optimal length of treatment.
Nevertheless, he noted that many clinicians adopted a 14-day course, an approach which he labelled as ‘misguided’ in part because of the presumed causes of exacerbations together with the vast heterogeneity seen in patients with an exacerbation.
Instead, Dr Stephen said he preferred a more ‘flexible’ approach where patients are assessed daily based on symptoms and pulmonary function testing, with the length of antibiotic treatment “tailored to each individual exacerbation”.
Conceding that guidelines had advantages in that they standardised care and provided guidance to clinicians, “locking in patients” to a set duration of antibiotic treatment would “most likely cause some patients to be undertreated and others to be overtreated,” he argued.
“Barring any future biomarker discovery, the most beneficial approach is to treat until symptoms are reasonably improved and the patient feels close to baseline with exercise capacity.”