Long-term quinine use for idiopathic leg cramps or restless leg syndrome is associated with an increased mortality risk. The UK findings, published in a JAMA Research Letter, support previous warnings about the off-label use of quinine. The US Food and Drug Administration (FDA) has repeatedly warned about the risks of quinine including life-threatening hypersensitivity reactions, ...
Quinine risks greater than benefit for leg discomfort
By Mardi Chapman
10 May 2017