Australian oncologists have significantly divergent views on the place of durvalumab in treating Stage III lung cancer, which is reflected in their ‘variable’ prescribing practices, survey data show.
The almost polar opposite responses given by the oncologists highlight the need for local practice guidelines for the PD-1 checkpoint inhibitor, the researchers say.
Some 32 local medical oncologists specialising in thoracic cancer answered the poll between May and July last year about their prescribing for patients with various subcategories of stage III unresectable disease.
Only two (6%) stated they prescribed durvalumab for all patients with EGFR-mutations, while another two respondents said they strongly recommended treatment in this group.
On the other hand, 44% suggested there was “little benefit” of consolidation durvalumab in the EGFR cohort, with an additional 19% advocating for observation only.
There was also a wide variance in oncologists’ positions on use of the drug in patients with PD-L1 negative NSCLC: 13% prescribed it for all such patients, while an additional 56% strongly recommended treatment. But here too, a significant number took the opposite approach.
But this was variability was no sign that any doctor had ‘gone rogue’, stressed the researchers, all oncologists from hospitals in Western Sydney.
Indeed, international guidance was itself heavily conflicted, they wrote in Oncology (link here).
In particular ASCO guidelines advocated for consolidation durvalumab in unresectable stage III NSCLC irrespective of their PD-L1 expression and mutation status. But ESMO differed, with consolidation durvalumab only recommended in those patients who expressed PD-L1(i.e.,>1%), they noted.
“Currently, in Australia, there is no consensus practice guideline on how to manage these patients, undoubtedly leading to differing clinical approaches,” the authors added.