oncology
Blood

Rebuilding bone in multiple myeloma

Dr Michelle McDonald

Dr Michelle McDonald is a lead researcher at the Bone Biology Division in the Garvan Institute of Medical Research.

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An antibody that inhibits the bone-regulating protein sclerostin and effectively stimulates bone formation has been shown to increase bone mass, bone strength and resistance to fracture in experimental models of multiple myeloma. A combination of the anti-sclerostin antibodies and the bisphosphonate zoledronic acid was also found to increase bone volume more than either agent alone. ...

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