Drugging the undruggable? KRAS inhibitor shows early promise

Selective inhibition of the KRAS p.G12C mutation is offering some promise for patients with locally advanced and metastatic solid tumours. A phase 1 trial of sotorasib in 129 patients – including Australians – with mainly non-small cell lung cancer (NSCLC) and colorectal cancer (CRC) has found no dose-limiting toxic effects or treatment-related deaths associated with ...

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