Associate Professor Nicholas Saunders: Resetting the drivers of anthracycline resistance

Researchers have identified a strategy to repurpose anthracyclines for use in advanced, drug-resistant head and neck squamous cell carcinomas (HNSCC). The research found the transcriptional inhibitor E2F7 is mislocalised to the cytoplasm in more than 80% of human HNSCCs. Meanwhile its counterpart, the transcriptional activator E2F1, retains localisation in the nucleus of the cancer cells ...

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