Female patients and those not currently working are likely to face longer delays in receiving a myasthenia gravis diagnosis than those who are male and employed, an Australian study suggests.
The retrospective study involved 110 patients (56% female) from three Melbourne institutions. Most initially presented with purely ocular symptoms, particularly those older than 50.
Almost two-thirds of ocular patients generalised within two years.
Generalised patients, who eventually made up 70% of the cohort, were identified as having bulbar, respiratory, or generalised weakness, with or without ocular complaints. More female than male patients presented as early-onset myasthenia gravis (MG), which was defined as younger than 50.
Researchers, led by Dr Minh Nguyen from the Department of Neuroscience at Monash Health, said potential precipitants of MG were only apparent in one-third of patients, the most common being major surgery and prior infections.
Findings published in Neurology Clinical Practice [link here] revealed that the median time from symptom onset to MG diagnosis was 102 days, with most patients (90%) receiving a definitive diagnosis within one year.
Two-thirds of diagnoses were made in outpatient settings, with most in neurology/neuro-ophthalmology, 5% in ophthalmology and 2% in general medicine settings.
Overall, female patients took longer to be diagnosed than male patients (median 145 days vs 54 days), while the biggest contributor to prolonged diagnosis was the time between symptom onset and initial presentation (median 17 days).