Impacts of MS HRQoL ‘substantially worse’ in progressive vs relapse onset
Patients with progressive onset MS (PROMS) report experiencing ‘substantially worse’ physical and and psychosocial impacts of their condition compared to patients diagnosed with relapse onset MS (ROMS), an Australian review has highlighted.
The findings from a sample of more than 1,570 participants in the Australian MS Longitudinal Study, persisted even when taking age, sex, disease duration and DMTs use into account. The largest difference was seen in independent living (-0.12), followed by relationships (-0.07), selfworth (-0.07) and coping (-0.04), say investigators from the Menzies Institute for Medical Research in Tasmania.
And while no significant differences were observed between the two onset types on physical health dimensions of pain investigators said mean pain scores were substantially lower than mean senses scores in both types, suggesting MS’s impact on pain is much stronger across both ROMS and PROMS
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Study defines prognostic value of low arterial oxygenation saturation in acute stroke
An arterial oxygen saturation (SaO2) around 96–97% is associated with the highest chance of functional recovery from acute stroke, according to a new analysis of the international Head Positioning in acute Stroke Trial
The well-known randomised trial looked at lying flat versus sitting up head positioning in more than 11,000 patients with acute stroke across nine countries including in Australia.
Now a post hoc analysis of the cohort, this time looking at the prognostic significance of low SaO2, showed that any change in SaO2 outside of 96–97% is associated with poorer outcome after acute stroke.