Profound anhedonia a feature of FTD
Anhedonia should be considered as a primary presenting feature in patients with behavioural variant frontotemporal dementia (FTD), Australian research suggests.
Sydney University researchers found clinically significant anhedonia in a group of 87 patients with FTD, but not in comparable patients with Alzheimers disease or healthy controls
The researchers from the university’s Brain and Mind Centre also found marked atrophy in frontal and striatal areas of the brain related to diminished reward-seeking, in patients with frontotemporal dementia (FTD).
The paper’s senior author, Professor Muireann Irish from the University of Sydney’s Brain and Mind Centre and School of Psychology in the Faculty of Science, said despite increasing evidence of motivational disturbances, no study had previously explored the capacity to experience pleasure in people with FTD.
“This has stark implications for the wellbeing of people affected by these neurodegenerative disorders, she said.
The findings are published in Brain.
Epilepsy drugs may impact bone health
Children with epilepsy treated with anti-epilepsy drugs (AEDs) have a three-fold higher fracture prevalence than their healthy siblings, an Australian study has shown.
Data from 133 children with epilepsy (average age 11 years old) and 128 siblings of similar age found that there were 49 non-seizure-related fractures in children taking AEDs, compared with 21 lifetime fractures in the sibling control group, giving a 2.7 (95% CI 1.3–5.3, p = 0.007) times greater fracture prevalence. Duration of AED use and generalised tonic–clonic seizures (GTCS) were independent predictors of fractures (Odds Ratios 1.55 and 2.50, respectively).
The researchers led by Dr Sunita Kumar and Dr Peter Simm of the Department of Endocrinology and Diabetes, Royal Children’s Hospital, Melbourne, said further longitudinal prospective studies were required to further explore risk and the direct impact of epilepsy on bone health.
Kidney disease affects stroke risk prediction
The Modified CHADS2 score to estimate risk of ischaemic stroke (IS) in AF patients has the best, most consistent discrimination and calibration across the spectrum of kidney function.
Six commonly used risk scores for stroke were externally validated in a Swedish cohort study of 36,004 patients with AF.