Patients on natalizumab for RRMS will now be able to take their medication without an IV infusion, with the drug now available on the PBS as a pre-filled syringe for SC administration.
Eligibility will be open under the same criteria as the existing listing for the drug, branded Tysabri (Biogen), including that patients must be ambulatory and have at least two documented attacks in the preceding two years of commencing MS therapy.
As with the IV infusions, dosing is every four weeks, but the new form will allow more convenience, with injections able to be given by any health practitioner, according to the company.
It was approved by the Pharmaceutical Benefits Advisory Committee last March (link here).
“The submission states that natalizumab SC is less invasive, reduces the time required for drug administration, reduces post administration observation time and allows for administration to occur outside of the hospital setting,” the PBAC noted in its decision summary.
“The submission suggested that natalizumab SC would be administered by a general practitioner at consulting rooms.”
PBAC supports therapy for amyloidosis with polyneuropathy
Meanwhile, the PBAC has come out in favour of a listing for patisiran for the treatment of patients with (hereditary transthyretin-mediated) hATTR amyloidosis with polyneuropathy.