neurology
Neurodegenerative disorders

Guidelines developed for newly-recognised TDP-43 (LATE) dementia

The first diagnostic criteria and guidance have been developed for a newly recognised form of non-Alzheimer dementia known as limbic-predominant age-related TDP-43 encephalopathy (LATE). Published in Brain, the consensus-based recommendations on LATE describe it as a dementia syndrome typically affecting older patients with neuropathological change defined by a stereotypical TDP-43 proteinopathy, with or without coexisting hippocampal ...

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