Gait stability is a more sensitive indicator of neurodegeneration than currently used measures such as walking speed in people with early multiple sclerosis (MS) and low disability scores, an Australian study reports.
The trial compared gait stability in 25 people with MS and 15 healthy controls. MS patients were Expanded Disability Status Scale (EDSS) 0-2 with no evident gait changes on standard clinical examination and a 3D motion capture system was used to record marker kinematics in participants walking for 5 mins on a treadmill at a fixed walking speed.
Data included step time, step width, stride time, cadence and local divergence exponents (LDE) which were calculated across multiple planes as a measure of gait stability.
Participants also had whole-body scans using ultra-high field 7-Tesla MRI, 3D T1-weighted structural scans of the brain and DWI tractography.
The study, published in the Multiple Sclerosis Journal (link), found that people with MS had higher LDEs or lower stability than healthy controls.
As well, lower gait stability was associated with greater tract damage in MS patients.
“We found that of all tract measures, CSTFDC [a combined measure of fibre density and fibre cross-section in the corticospinal tract] was the main predictor (significant) of gait stability when measured at both sacral and cervical levels.”
“These findings highlight the importance of the CST integrity to maintain the functionality of gait, particularly stability.”