GABA disruption in medial prefrontal cortex may be key to emotional impact of chronic pain

Australian neuroscientists have found evidence to support the hypothesis that chronic pain is associated with emotional problems due pathological changes that cause neurotransmitter dysregulation in the medial prefrontal cortex (mPFC). Researchers at the Centre for Pain IMPACT,  NeuRA and UNSW Sydney observed significantly decreased levels of glutamate and GABA+ in the mPFC of people with ...

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