Circadian disruption could be a prodromal feature or a risk factor for Parkinson disease, according to new US research.
The substudy of the Osteoportoic Fractures in Men Study comprised almost 3,000 men with a median age of 76 years who were living in the community. Data on rest-activity rhythm (RAR) and sleep variables was available from a wearable actigraph.
During a follow-up of 11 years, 2.7% of men were diagnosed with Parkinson disease (PD).
The study, published in JAMA Neurology found the risk of incident PD increased with decreasing circadian amplitude, mesor or robustness.
“Those in the lowest quartile of amplitude, mesor, or robustness had triple the risk of developing PD compared with those in the highest quartile of amplitude (OR, 3.11; 95% CI, 1.54-6.29), mesor (OR, 3.04; 95% CI, 1.54-6.01), or robustness (OR, 2.65; 95% CI, 1.24-5.66),” the study said.
“Reduced circadian rhythmicity might be an important prodromal feature in incident PD and help with the early detection of the disease.”