Amyloid beta fibril structure under the microscope

The structure of amyloid beta (Aβ) fibrils isolated from the brain tissue of patients with Alzheimer’s disease has been shown to differ from laboratory-derived fibrils. The research, published in Nature Communications, found brain-derived Aβ fibrils had a right-hand twisted structure – strikingly different from the left-hand twist seen in lab-derived fibrils. As well, cryo-electron microscopy of fibril ...

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