The structure of amyloid beta (Aβ) fibrils isolated from the brain tissue of patients with Alzheimer’s disease has been shown to differ from laboratory-derived fibrils. The research, published in Nature Communications, found brain-derived Aβ fibrils had a right-hand twisted structure – strikingly different from the left-hand twist seen in lab-derived fibrils. As well, cryo-electron microscopy of fibril ...
Amyloid beta fibril structure under the microscope
By Mardi Chapman
30 Oct 2019