AFFINITY trial is final nail in coffin for SSRIs in stroke recovery

The Australian-led AFFINITY (Assessment of Fluoxetine In Stroke Recovery) study has confirmed that SSRIs do not improve recovery after stroke. While previous trials have given conflicting results, the randomised controlled trial involving 1280 patients found that oral fluoxetine 20 mg daily for six months after acute stroke did not improve functional outcome and was associated with higher rates of ...

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