Time to look closer at the ‘dark side’ of G-CSF

The indirect benefit of granulocyte-colony stimulating factor (G-CSF) in supporting patients on chemotherapy may be masking its ‘dark side’ – the potential to promote tumour progression and metastasis. A review of the pre-clinical data on G-CSF provides strong evidence that the cytokine can stimulate tumour cell proliferation and promote angiogenesis. G-CSF has also been implicated ...

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