The prevalence of clinically significant red blood cell antigens beyond ABO and RhD is changing, reflecting the increasingly multicultural nature of the Australian population.
A study of 490,491 blood donors including 103,798 (21.2%) first-time donors during the calendar year 2019 comprised extended Rh (D, C, E, c and e), Kell (K), Duffy (Fy) and Kidd (Jk) typing as well as S and s antigens in the MNS blood group system.
Australian Red Cross Lifeblood (Lifeblood) has performed routine phenotype testing of Rh and Kell in blood donors since 2006.
Additionally, with increasing demand for phenotyped red cell units particularly for patients with frequent transfusion needs, Lifeblood introduced automated analysers in March 2019 to phenotype selected blood donors for other clinically significant blood group antigens.
The study, published in Pathology [link here], found the prevalence of R1R1 phenotype (D+ C+ E– c– e+) was 20.6% in the total blood donor group and 24.0% in first-time donors.
Yet previous estimates showed the prevalence of R1R1 was 17.3%, the researchers said.
“Overall, the study indicates that the R1R1 phenotype has increased in proportion from previous estimates and that this phenotype is more common in individuals that are group B or AB,” the study said.
“As previously reported group B and AB are more prevalent in people from countries such as China and India, where Australia has experienced relatively high immigration.”
The study also found the prevalence of rr (D– C– E– c+ e+) was slightly higher for the total donor panel compared to previous estimates (19.8% v 16.4%) “as these individuals are preferentially recruited”, but lower in first-time donors (15.2%).
“Therefore, in cases where rr blood is transfused into R1R1 recipients, anti-c antibodies may subsequently form. The formation of this antibody may not be significant in all transfusion settings, but in cases where an R1R1 person requires emergency obstetric transfusion and rr blood is used, the patient could require monitoring for possible development of haemolytic disease of the fetus and newborn (HDFN) during pregnancy.”
In other clinically significant blood group antigens, Fy (a–b–) was most commonly found in donors from Africa (e.g., Zimbabwe, Egypt, Sudan) or Asia (e.g., Iran, Saudi Arabia) and Jk (a–b–) was most commonly found from donors from Asia (Philippines) or donors with a Polynesian background (Tonga, Samoa, New Zealand).