Blood cancers

Drug transporter over-expression contributes to imatinib resistance in CML

Over-expression of the ABCB1 drug transporter and loss of active drug from target cells explains at least some cases of imatinib resistance in chronic myeloid leukaemia, new research from Adelaide suggests. Dr Laura Eadie, from the South Australian Health and Medical Research Institute, and colleagues found that patients who had ABCB1 mRNA expression above the ...

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