Anticoagulant antidote works within minutes

The anticoagulant effects of apixaban and rivaroxaban are reversed within minutes by the antidote andexanet, studies published in the NEJM show. The two drug company sponsored studies treated 145 healthy volunteers aged 50-75 with either apixaban (5 mg twice daily) or rivaroxaban (20 mg daily). Subjects were then randomised to andexanet given either as a ...

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