Australian patients with chronic pain show improvements in quality of life and fatigue after being prescribed medicinal cannabis, according to an industry sponsored study.
University of Sydney researchers conducted a three-month follow up survey of 2327 Australian patients with chronic health issues who were prescribed medicinal cannabis (THC and CBD dissolved in a medium-chain triglyceride carrier oil) between November 2020 and December 2021.
The most-reported conditions being treated were chronic pain (69%); insomnia (23%); anxiety (22%); and anxiety/depression (11%); half of patients were being treated for more than one condition. Two thirds (63%) of the surveyed patients were female, with an average age of 51 years.
Patients were surveyed about their self-reported health-related quality of life, pain, sleep, anxiety, and depression prior to beginning cannabis therapy, after two weeks of treatment, then once a month for three months.
The survey showed that during the first three months of use of medicinal cannabis, there were significant and ‘clinically meaningful’ improvements in health-related quality of life and fatigue , along with improvements in anxiety, depression and pain.
However, cannabis therapy did not seem to improve reported sleep disturbances, according to a study published in PLOS ONE (link here).
The study investigators reported that health-related quality of life as measured by EQ-5D-5L utility scores and QLQ-C30 summary scores showed clinically meaningful improvement in the overall cohort from baseline to mean follow-up with d = 0.54 (95%CI:0.47 to 0.59) and d = 0.64 (95% CI:0.58 to 0.70) respectively. They noted that there was a suggestion of lesser improvement in quality of life in older patients.
There was also clinically meaningful improvement in fatigue (PROMIS Fatigue T-scores; d = 0.54; 95%CI:0.48 to 0.59) in the overall cohort.