Foods high in fructans and mannitol most commonly trigger IBS symptoms in patients, according to a blinded reintroduction phase trial for the low FODMAP diet.
The Belgium-led study, which included an Australian researcher, also confirmed that symptoms significantly improved by following a low FODMAP diet.
Researchers recruited 117 patients (mean age 36, 84% female) with an IBS diagnosis who followed a six-week strict low-FODMAP diet before responders entered a nine-week blinded randomised reintroduction phase.
The reintroduction phase involved six FODMAP powders (fructans, fructose, galacto-oligosaccharides, lactose, mannitol, sorbitol) or glucose as a control.
Powders were administered in daily amounts in a cross-over order with a two-day wash-out period between each powder at the end of day seven.
Patients completed daily symptom diaries and questionnaires for quality of life and psychosocial co-morbidities. A FODMAP-trigger was defined as a rise of ≥50 points on the IBS Severity Scoring System (IBS-SSS).
Findings published in Gastroenterology [link here] revealed that IBS-SSS improved significantly after the elimination period compared to baseline (150 [mild IBS severity] versus 301 [severe IBS severity], 80% responders).
Symptom recurrence was triggered in 85% of patients who entered the reintroduction phase by an average of 2.5 different FODMAPs per patient.
The most prevalent triggers were fructans (56%) and mannitol (54%), followed by galacto-oligosaccharides (35%), lactose (28%), fructose (27%), sorbitol (23%), and glucose (26%).