Allopurinol enables more IBD patients to get remission from thiopurines

Many IBD patients who are intolerant or unresponsive to thiopurines can have good clinical responses if the drugs are used in low doses combined with allopurinol, Victorian clinicians have shown. Allopurinol favours production of the active metabolite 6TGN (thioguanine nucleotides) from IBD drugs such as azathioprine and mercaptopurine over the inactive thiopurine metabolite 6MMP that ...

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