This is the first of a three-part package on how diseases evolve when we change the way we live. Part two, tomorrow, will explore the origins of anorexia and how mental illness is shaped by time and culture. Part three, on Friday, will examine the causes of Zika, Ebola and SARS and how disease outbreaks can be prevented.
A virus is essentially an information system (encoded in DNA or RNA) surrounded by a protective coat and shaped by evolution to ensure its own replication and survival.
Viruses grow only in living cells. But they infect everything from the simplest, single-cell organisms, such as amoebae, to multicellular, multi-organ ecosystems like us.
Bacteria, on the other hand, are cells in their own right and carry all the molecular machinery needed for their reproduction. As a consequence, they have unique biochemical pathways that can be targeted by broad-spectrum antibiotics.
Antiviral drugs tend to be unique for the particular virus, or closely related family of viruses. This has made them much less available than antibacterial drugs.
Tracing our molecular history
Evidence of our long history of infection is found in ancient fragments of viral DNA that have passed from mother to foetus. These are not known to cause problems and may even be of some benefit.
Every human also has a “virome” of persistent pathogens they’ve contracted since birth. Herpes simplex type 1 (which causes cold sores),Epstein Barr virus (which causes glandular fever or “kissing disease” in adolescents) and cytomegalovirus (also a member of the herpes family), for instance, stay with us for life.
Gene sequence analysis allows us to infer how long Homo sapiens has been associated with particular viruses. There is evidence, for example, that lineages of human T cell leukemia virus type 1 (HTLV1), a virus that grows only in us to cause leukemia and other diseases, has been around for many thousands of years.
The original Australians carry two “strains” of HTLV1 that are thought to have diverged more than 9,000 years back and which are a significant and under-recognised cause of illness in some Indigenous communities.
Piecing together the rest
Humans have a deep history of viral infections, but other than the molecular analysis of current or recently circulating pathogens, the data is fragmentary.
That may change as researchers probe more ancient DNA from Egyptian mummies, where there is evidence of lethal tuberculosis and malaria (neither of which is viral) dating 1,500 to 4,000 years back. The evidence so far suggests mummies suffered from smallpox and polio.
![](https://62e528761d0685343e1c-f3d1b99a743ffa4142d9d7f1978d9686.ssl.cf2.rackcdn.com/files/117623/width754/image-20160406-29002-ueyv3x.jpg)
With recorded history, we are limited to much more recent accounts. From 430-427 BCE, the Plague of Athens, described by Thucydides, killed more than one-third of the population. The cause is unknown, though the favoured candidate is the bacterial infection typhus.
Then the Antonine plague (165-180 CE), also called the Galenic plague after the great Roman physician, was likely viral, with smallpox being the probable cause.
Chinese paediatrician Wan Quan (1495-1585) identified smallpox and, around that time, the Chinese began the process of “immunising” healthy subjects by blowing powdered smallpox scab material up the nose.
Recognisable descriptions of influenza outbreaks date back to 1580, with three such events during each of the 19th and 20th centuries.
Setting aside HIV/AIDS, which may be regarded as a “continuing” (since 1981) pandemic, the worst pandemic of modern times was the 1918/19 Spanish flu that killed 40-50 million people globally. Spain gets a bad rap for this: the virus had been active in the trenches on the western front for months, but neither set of combatants wanted to admit their armies were being weakened.