Patients with hidradenitis suppurativa treated with the interleukin-17 A and F antagonist bimekizumab-bkzx (Bimzelx) showed clinically meaningful improvements in skin pain up to 48 weeks, according to results released at AAD 2024.
Post-hoc analyses of pooled Phase 3 data from the BE HEARD I and BE HEARD II studies showed that bimekizumab produced sustained improvements in skin pain and draining tunnels compared to placebo in adults with moderate-to-severe hidradenitis suppurativa (HS).
In the study, 1014 patients were randomised to receive either bimekizumab 320 mg every two weeks, four weeks or placebo.
The results showed that patients treated with bimekizumab reported clinically meaningful improvements in skin pain up to 48 weeks across various assessed outcomes, including the HS Symptom Questionnaire (HSSQ) skin pain item, the Patient Global Impression of Severity of Skin Pain (PGI-S-SP) and the Change in Severity of Skin Pain (PGI-C-SP).
At Week 48, HSSQ skin pain response was achieved by 64.6–75.7% of patients and a HSSQ skin pain score of 0 was achieved by 12.7–19.8% of patients. Skin pain scores reduced by 36.9–43.7% across treatment groups.
Additionally, patients treated with bimekizumab demonstrated greater reductions in draining tunnel count compared to those on placebo at Week 16. Responses were either sustained or improved to Week 48.