Risk factors

Why were the results of EMPA-REG so surprising?

Diuresis with associated glucose and sodium excretion might help explain the “highly impressive and unexpected” reductions in heart failure hospitalisation, all-cause death and cardiovascular death in the EMPA-REG Outcomes study of empagliflozin, a recent review has suggested. As one of a large number of FDA-mandated studies to establish the cardiovascular safety of newer treatments for ...

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