There is now enough evidence of ‘extra‐glycaemic’ benefits of SGLT-2 inhibitors on cardiovascular and renal function to justify them being used irrespective of glycaemic control, Australian experts say.
The presence of comorbidities such as atherosclerotic cardiovascular disease, heart failure and chronic kidney disease (CKD) should guide the use of SGLT2 inhibitors rather than HbA1c levels or glucose response, according to clinicians in the Department of Endocrinology and Metabolism at St Vincent’s Hospital, Sydney.
In a letter to the Internal Medicine Journal they note that results from landmark trials have shown that the cardiovascular and renal benefits of SGLT2 inhibitors are very likely independent of baseline glycaemia and the glucose-lowering effects of the drugs.
They cite the example of the DAPA-HF trial, in which patients with symptomatic heart failure with reduced ejection fraction randomised to dapagliflozin had a significantly lower risk of worsening heart failure or cardiovascular death compared to placebo, irrespective of the presence of diabetes.
And similarly the CREDENCE trial showed that patients with type 2 diabetes and nephropathy had a significant reduction in end-stage kidney disease when treated with canagliflozin compared to placebo despite a minimal difference in HbA1c.
Cardiovascular benefits with SGLT2 inhibitors were also independent of glycaemic effects trials such as EMPA-REG OUTCOME, CANVAS and DECLARE-TIMI 58.