rheumatology
Gout

Cardiovascular warning for febuxostat

The US Food and Drug Administration (FDA) has added a boxed warning to febuxostat after a postmarketing safety clinical trial found an increased risk of cardiovascular-related death and all-cause mortality compared to allopurinol. The FDA said it was also limiting the approved use of febuxostat to second-line treatment in gout after allopurinol. “Health care professionals should ...

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