Bone trumping cartilage as the key to knee OA

Deficits in bone are emerging as the central underlying feature of knee osteoarthritis, raising the hope that treatments targeting bone might significantly modify the disease process, a recent review by Australian rheumatologists has concluded. Professor Flavia Cicuttini, head of rheumatology at the Alfred Hospital in Melbourne, and colleagues described how ‘Wolff’s law’ provides a rationale ...

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