GU Cancer

Call for targeted PSA screening in men with MMR gene pathogenic variants

Men with pathogenic variants in the mismatch repair genes associated with Lynch syndrome have a significantly increased risk of prostate cancer compared to men without those genetic variants. The international IMPACT study recruited 828 men aged 40-69 years with a known familial pathogenic variant (MSH1, MSH2 or MHS6) and 184 non-carrier controls from eight countries ...

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