New evidence supports discontinuation of antiseizure medications in neonates

Discontinuation of antiseizure medication (ASM) at discharge after acute symptomatic neonatal seizures appears to be safe. A comparative effectiveness study of 303 children found most (64%) were maintained on ASM, usually phenobarbital (90%), beyond resolution and discharge. The US study found the rate of impaired functional neurodevelopment at 24 months was similar in those discontinued ...

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