Blood cancers

Prof Miles Prince: genetic studies probe under the skin of rare T-cell lymphoma

A number of mutations causing T-cell immunoglobulin mucin 3 (TIM-3) alterations have been identified as the causative genetic defects in subcutaneous panniculitis-like T cell lymphoma (SPTCL). The international research published in Nature Genetics, comprised whole-exome and targeted sequencing on a series of 27 patients with SPTCL. It revealed missense variants in HAVCR2, which encodes TIM-3, ...

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