A number of mutations causing T-cell immunoglobulin mucin 3 (TIM-3) alterations have been identified as the causative genetic defects in subcutaneous panniculitis-like T cell lymphoma (SPTCL). The international research published in Nature Genetics, comprised whole-exome and targeted sequencing on a series of 27 patients with SPTCL. It revealed missense variants in HAVCR2, which encodes TIM-3, ...
Prof Miles Prince: genetic studies probe under the skin of rare T-cell lymphoma
By Mardi Chapman
21 Nov 2018