Blood cancers

Cognitive dysfunction linked to TKI withdrawal

A rebound increase in Abl activity after ceasing tyrosine kinase inhibitors in chronic myeloid leukaemia might be linked to the onset of neurodegeneration and cognitive dysfunction. Haematologists at the Hammersmith Hospital in London have described three women with CML who were treated sequentially with three or four TKIs, most recently nilotinib or imatinib, over a ...

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