ARISTOTLE says to avoid combinations of DOACs and NSAIDs

Concomitant use of NSAIDs and oral anticoagulants (DOACs) – including DOACs – may increase the risk for major bleeding, according to a new post hoc analysis of the ARISTOTLE trial. Study investigators analysed data from 17,423 individuals who took part in the trial comparing apixaban with warfarin in patients with AF.  NSAID use was common: ...

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