Antibiotic interaction warning on DOACs bleeding risk

Co-administration of clarithromycin and a DOAC increases the small risk of a major haemorrhage in elderly patients. According to a Canadian study of 25,000 patients being treated with a DOAC and either clarithromycin or azithromycin, there was a significant difference in the 30-day rates of hospitalisation or an ED visit with major haemorrhage. Patients were ...

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