Blood cancers

ALL thiopurine study a ‘paradigm shift’ in understanding of how drug resistance develops

The question of whether acquired drug-resistance mutations in relapsed paediatric acute lymphoblastic leukaemia (ALL) pre-exist or are induced by treatment has been answered in part by an international study. Researchers in the US, Germany and China say their collaboration has found evidence of a specific mechanism by which thiopurine chemotherapy induced drug-resistance-associated mutations leading to ...

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