Top-down treatment versus a step-up strategy does not appear to result in increased clinical remission during long-term follow-up of patients with Crohn’s disease, a long term follow up study has shown. The findings contrast with the demonstrated short-term benefit of top-down treatment i.e. early combined immunosuppression in the pivotal 2008 Step-up/Top-down-trial. However the treatment landscape ...
Top down or step up? IBD treatment approach still not clear-cut
By Mardi Chapman
23 Mar 2018