gastroenterology

Tolerability data favour thiopurines over methotrexate

Trouble with the tolerability of conventional immunomodulators results in relatively high discontinuation rates despite their ongoing utility in the biologic era, Australian research shows. A retrospective study of 782 IBD patients on immunomodulators at two tertiary hospitals in Victoria has found discontinuation of methotrexate (40%) occurred at twice the rate as that of dose-optimised thiopurines ...

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