PPIs may promote C. difficile

Proton pump inhibitors may increase the risk of Clostridium difficile infection by altering the gut microbiome, the largest study to date shows. The research involving faecal samples from 1827 healthy twins found significant associations between the composition of the gut microbiota and PPI use. The most striking association was an increase in lactobacillales, particularly streptococcaceae, in PPI ...

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