New safety warnings for JAK inhibitors

The US Food and Drug Administration (FDA) is imposing new restrictions and warnings on JAK inhibitors after a tofacitinib safety trial showed an increased risk of major adverse cardiovascular events, malignancy, thrombosis, and mortality. The measures will apply to tofacitinib, baricitinib, and upadacitinib, based on results from a postmarketing safety trial of Pfizer’s tofacitinib in ...

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