Intestinal barrier may be key to fructose-induced liver damage

Fructose causes liver toxicity by first changing the barrier function of the intestine, a team of international researchers including Australians has found. The study, published in Nature Metabolism, showed that a prolonged, high fructose diet induces barrier deterioration, a low-grade endotoxaemia, and intestinal epithelial endoplasmic reticulum (ER) stress in experimental animals. Importantly, treatments that prevent ...

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