Using frozen faeces for microbiota transplantation appears to be just as good as using the fresh stuff, a study in JAMA reports.

Among a group of adults with recurrent or difficult to treat Clostridium difficile infection the use of frozen FMT did not result in a significantly lower rate of resolution of diarrhea compared to using fresh FMT the researchers from McMaster University, Hamilton, Ontario, Canada found.

Findings for frozen FMT and fresh FMT were similar in terms of safety, the authors noted.

“Given the potential advantages of providing frozen FMT, its use is a reasonable option in this setting,” they concluded.

 An accompanying editorial said the ability to use frozen stool eliminates many of the logistical burdens inherent to FMT, because stool collection and processing need not be tied to the procedure date and time.

The study also provided greater support for the practice of using centralized stool banks, which could further remove barriers to FMT by making available to clinicians safe, screened stool that can be shipped and stored frozen and thawed for use as needed, it said.

The findings back calls made by GESA in a position statement last year to set up frozen stool banks across the country so that all patients with recurrent or refractory CDI have access to faecal transplants.

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