Avoid concomitant allopurinol and 6-mercaptopurine/azathioprine

The concomitant use of allopurinol with 6-mercaptopurine or azathioprine should be avoided because of a potentially dangerous interaction, the TGA has said in its latest safety advisory. According to the advisory allopurinol reduces metabolism of 6-mercaptopurine and azathioprine, significantly increasing the risk of potentially fatal bone marrow toxicities and blood dyscrasias, including leukopenia, thrombocytopenia and ...

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